Abstract Background Inhibition of kinases involved in the DNA damage response sensitizes cells to genotoxic agents by abrogating seat knob checkpoint-induced cell cycle arrest.CHK1 and WEE1 act in a pathway upstream of CDK1 to inhibit cell cycle progression in response to damaged DNA.Therapeutic targeting of either CHK1 or WEE1, in combination with

The M/V Marathassa oil spill occurred on 8 April 2015 in the English Bay.In the present study, the trajectory and the transport mechanism of the spilled oil have been studied by using the three-dimensional and particle-based Oil Spill Contingency and Response (OSCAR) model forced by the Finite-Volume Community Ocean Model (FVCOM).FVCOM provided the

We report the finding of alkaline phosphatase-immunoglobulin complex (macro-alkaline phosphatase (macro-ALP)) in a patient with persistently increased ALP activity.The identification of macro-ALP is important Safety to rule out pathological causes of increased ALP activity and to avoid unnecessary diagnostic investigation.The patient was subsequent

For many years a discussion has been in progress within regional research on the significance of regional corporate clusters, which in the light of the global reorganisation of value-added chains have come to take on a key function for spatial structure and in achieving greater efficiencies.The model of a regional production and redistribution seat

The Indonesian Navy (TNI AL) is required to have a persistently broad Maritime Rods Domain Awareness (MDA).In meeting its MDA demands, apart from using the KRI Radar, the Indonesian Navy needs to be supported by other airborne surveillance sensors and sensing satellites in outer space.For airborne sensors, Puspenerbal has been equipped with a fleet